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Showing 54 studies.
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Feasibility of a Treadmill Based Step-Targeting System for Children and Young Adults with Hemiplegic Cerebral Palsy: A Pilot Study
This study is testing a new treadmill-based walking training system that uses real-time visual feedback to help children and young adults with hemiplegic cerebral palsy practice taking more symmetrical steps. Participants will walk on a treadmill while following visual stepping targets, and researchers will evaluate how the system affects walking patterns and gather feedback about the user experience. Compensation is provided. R-1321-26
Investigator Peter Barrance ,PhD
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Person-Centered Goal Setting to Enhance Rehabilitation Engagement after Stroke: A Pilot fMRI Study
No description found, try our website link in blue
Investigator Hayejin Kim, PhD, OTR/L
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KF-STRIDE® Into Life: Adapting of a Web-Based Intervention Enhancing Personal Strengths to Improve Self-Concept after SCI
People with SCI often face many challenges which can change how they view themselves. This study will adapt an online wellness tool based in positive psychology, called Kessler Foundation’s STRength IDentification and Expression Into Life (KF-STRIDE® Into Life) to help people with SCI identify and apply their character strengths and use positive coping strategies when faced with challenges in daily life. E-1315-26
Investigator Amanda Botticello ,PhD
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Physical Activity in Transition-Age Youth on the Autism Spectrum (Study 1)
The goal of this study is to understand and improve physical activity in youth on the spectrum. R-1305-25
Investigator Yu-Lun Chen ,MS, ORT
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Evaluating the Bambini Teens Exoskeleton for Pediatric Cerebral Palsy
This study aims to assess the safety and effectiveness of the Bambini robotic exoskeleton as a walking training tool for children with cerebral palsy. R-1303-25
Investigator Karen Nolan ,PhD
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Enhancing Reading Recovery in Post-Stroke Aphasia with Electrical Brain Stimulation and Phono-Motor Treatment
This study assesses whether adding electrical stimulation to existing aphasia treatments improves the ability to read in people who have had a stroke. R-1290-25
Investigator Olga Boukrina ,PhD
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Cardiovascular Response to Stimulation & Interventions in First-Year Spinal Cord Injury
The study aims to investigate how transcutaneous spinal stimulation (spinal stimulation through the skin) affects blood pressure in individuals with recently acquired spinal cord injury, with evaluations extending through the first year post-injury. Additionally, it will monitor cardiovascular function changes during this period. The study will commence during inpatient hospitalization at Kessler Institute for Rehabilitation, a Select Medical hospital, and will continue after discharge, with participants returning as outpatients. R-1287-25
Investigator Steven Kirshblum ,MD
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MRI Research on Motivated Learning in Multiple Sclerosis
This study looks at how the brain responds when people are motivated to learn from feedback about their memory. It examines how that feedback helps them improve, and what happens in the brain when that learning takes place. Participants will complete a computer task that requires decision-making and memory, part of which will be completed inside an MRI scanner. Participants will also complete a few paper-and-pencil thinking tests and questionnaires. R-1285-24
Investigator Christopher Cagna ,MS
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Neuromodulation Enhanced use of Robotic Balance Training (NEUROBALANCE) to Improve Balance Function in Individuals with Stroke
The purpose of this research study is to determine if a new robotic balance training program can improve balance function and postural control when combined with brain stimulation, in people with stroke. R-1279-24
Investigator Vikram Shenoy Handiru ,
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Personalized Virtual Reality-based Training to improve Gait and Balance and Reduce Falls in Older Adults with MCI
This study assesses the effectiveness of combining thinking tasks with walking training to improve walking and balancing ability and reducing falls in older adults with mild cognitive impairment. R-1276-24
Investigator Soha Saleh ,PhD
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Robotic Exoskeletons Training for People with Stroke
This study assesses the effectiveness of overground walking training with different wearable robotic exoskeletons to determine the impact on mobility for individuals with different walking needs post stroke. R-1275-24
Investigator Karen Nolan ,PhD
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Help Develop a New Survey About Personal Assistance and Spinal Cord Injury
This fully remote study helps design a new survey to explore how receiving personal assistance affects the well-being of people with SCI. Participants will complete questionnaires and attend a 2-hour online focus group during one day. E-1270-24
Investigator Jeanne Zanca ,PhD
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The PUPIL (Play,Understand,Partner,Interact,and Learn) Program: Developing a caregiver curriculum and game to supplement an evidence-based cognitive rehabilitation protocol
Group discussions will be held to collect feedback on a newly developed game and curriculum related to using memory strategies in daily life. E-1267-24
Investigator Aubree Alexander ,PhD
Join the study “The PUPIL (Play,Understand,Partner,Interact,and Learn) Program: Developing a caregiver curriculum and game to supplement an evidence-based cognitive rehabilitation protocol” Learn more about “The PUPIL (Play,Understand,Partner,Interact,and Learn) Program: Developing a caregiver curriculum and game to supplement an evidence-based cognitive rehabilitation protocol” -
Impact of TBI on Functional Recovery and Everyday Activities
We want to follow individuals with moderate to severe TBI over time. We will measure how the TBI has impacted recovery and activities of daily living. R-1264-24
Investigator Peggy Chen ,PhD
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Establishing a Clearer Measure of Mental Fatigue in Multiple Sclerosis
This study examines mental fatigue that is regularly experienced by people with multiple sclerosis. Researchers will examine levels of mental fatigue by looking at brain activation during an MRI scan and analyzing self-reported mental fatigue provided during study participation. R-1263-24
Investigator Glenn Wylie ,Dphil
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Personalized Virtual Reality Walking and Balance Training for TBI
This study aims to learn whether personalized training that combines thinking and movement tasks can improve walking and balance in people who have had traumatic brain injuries. R-1262-24
Investigator Kiran Karunakaran ,PhD
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Brain Stimulation and Robotic Balance Training after Traumatic Brain Injury
This study aims to improve balance control in individuals with traumatic brain injury, a common challenge affecting mobility and stability. The study will evaluate the effects of 15 sessions over five weeks, combining a robotic balance platform with real or sham brain stimulation. This clinical trial will assess its impact on balance function and postural control. R-1261-24
Investigator Vikram Shenoy Handiru ,
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Ecological Assessment for Chronic Spatial Neglect
This study evaluates a new assessment for spatial neglect. People with spatial neglect often pay much more attention to one side of the body while ignoring the other side even though they have no difficulty seeing. This new, investigational assessment is called the Kessler Foundation Neglect Assessment Process with 13 items (KF-NAP®-13). This study seeks to determine if the new assessment is better than existing tests in detecting spatial neglect in persons who had a stroke more than 6 months ago. E-1257-24
Investigator Peggy Chen ,PhD
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Locomotor and Bladder Function in Individuals with Spinal Cord Injury
This study demonstrates that epidural stimulation may be a method for improving stepping, standing and bladder function in people with spinal cord injury. This type of stimulation is given near the spinal cord through a device that is placed inside the body during a surgery. R-1254-24
Investigator Gail Forrest ,PhD
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Using the Eyes to Study the Brain
This study explores a new set of hands-free tests that will assess ability to learn new information and how quickly participants process information. These new tests use a system that measures the movement of your eye (an 'eye tracking system') to record responses to various thinking tasks. E-1252-24
Investigator Silvana Lopes Costa ,PhD
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A Strength-Based Intervention to Improve Job Interview Skills in Young Adults with ADHD
This fully remote study evaluates how effective a strength-based intervention is in improving job interview skills in young adults with ADHD who may have difficulty with job interviews or want to improve these skills. E-1251-24
Investigator Helen Genova ,PhD
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Understanding Wheelchair Breakdowns
This fully remote study explores social, cultural, emotional, and environmental factors that impact wheelchair breakdowns and repairs. E-1250-24
Investigator Denise Fyffe ,PhD
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Improving Balance Using a Robotic Upright Stand Trainer and Spinal Cord Epidural Stimulation
This study investigates how standing and sitting balance control is altered after spinal cord injury and how a new type of robotic assistive device may be used to improve muscle function. R-1243-23
Investigator Enrico Rejc ,PhD
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Exercise and Reading Therapy After Stroke
This study tests the effectiveness of reading therapy combined with exercise (stationary bike cycling or stretching) for people who have difficulty reading after a left-brain stroke. R-1242-23
Investigator Olga Boukrina ,PhD
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A Strength-Based Tool to Enhance Employment for Adults on the Autism Spectrum
This fully remote study evaluates the effectiveness of our intervention designed to improve job interview skills in adults with autism. E-1238-23
Investigator Helen Genova ,PhD
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Memory and Learning Rehabilitation Combined with Exercise Training in Multiple Sclerosis
This study compares the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory in people with multiple sclerosis and mobility disability. R-1233-23
Investigator Carly Wender ,PhD
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Effects of Epidural Stimulation in People with Acute Spinal Cord Injury
This study evaluates the effects of epidural stimulation of the spinal cord and task-specific training on motor control, cardiovascular and respiratory functions, bowel, bladder, and sexual function in individuals with spinal cord injury. R-1230-23
Investigator Claudia Angeli ,PhD
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Quantification of Micro-Fragmented Adipose Tissue or Body Fat
Micro-fragmented adipose tissue (MFAT) or body fat is used to treat a variety of medical conditions including those that cause pain in muscles, tendons, and ligaments. The purpose of this research study is to analyze and compare the characteristics of different MFAT materials produced by four commercially available systems to see if all methods produce similar products or if one method is better over others. R-1226-23
Investigator Nathan Hogaboom ,
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The Effects of Effort on Fatigue and Brain Activity in TBI
This study examines how patterns of brain activity relate to cognitive fatigue, which is a feeling of exhaustion and inability to perform thinking-related activities. R-1224-23
Investigator Ekaterina Dobryakova ,PhD
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Informing a Caregiver-Driven Vision for Future Services and Supports
This fully remote study gathers input from family caregivers of people with SCI to better understand their needs and improve future support services and resources. E-1222-23
Investigator Denise Fyffe ,PhD
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Well-being Interventions for Adults with Traumatic Brain Injury
This fully remote study evaluates the effectiveness of two interventions to improve well-being in adults with traumatic brain injury. E-1220-23
Investigator Helen Genova ,PhD
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Comparing the Effectiveness of Upper Limb Tele-rehab and an Exercise Video Game in People with a Brain Injury
This study compares the effectiveness of an exercise video game (Exergame) and a home-based arm and hand exercise (HAHE) program to improve daily functions and quality of life in people with brain injuries who have impairments in the use of their arms and hands. E-1217-23
Investigator Peggy Chen ,PhD
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Social- and Health Care-Related Influences on Multiple Sclerosis Outcomes
This fully remote study looks at how social and health care factors affect disability, mood, and quality of life in people with MS. The survey is available in English and soon in Spanish. R-1216-23
Investigator Cristina Roman ,PhD
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Improving Arm Function Using a Powered Wearable Orthotic After a Spinal Cord Injury
This study evaluates the usefulness of an upper extremity assistive device called MyoPro in improving upper extremity activities in people with incomplete spinal cord injury (iSCI). R-1215-23
Investigator Ghaith Androwis ,PhD
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Spinal Cord Transcutaneous Stimulation for Upper Extremity Function Recovery in Acute to Subacute Cervical Spinal Cord Injury
This study aims to understand the safety and practicality of providing stimulation to the spinal cord through the skin (referred to as 'transcutaneous stimulation') in people who are receiving inpatient rehabilitation. The study will also determine if combining stimulation with therapy that involves the upper limbs can improve participants' ability to use their hands, arms, and trunk during inpatient treatment at Kessler Institute for Rehabilitation. R-1212-23
Investigator Fan Zhang ,PhD
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ReSUME Hand Exergaming Study for Stroke
No description found, try our website link in blue
Investigator Vikram Shenoy Handiru, PhD
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Blood Pressure Changes with Transcutaneous Spinal Stimulation in a Recently Acquired Spinal Cord Injury
This study examines the use of spinal stimulation applied through the skin (referred to as transcutaneous spinal stimulation) in treating orthostatic hypotension (a drop in blood pressure when moving from lying flat on your back to an upright position) in individuals with a recently acquired spinal cord injury, during inpatient rehabilitation. R-1206-23
Investigator Einat Haber ,PhD
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A Strength-Based Employment Maintenance Program for Individuals on the Autism Spectrum
This fully remote study evaluates the effectiveness of our intervention designed to improve job maintenance skills in youth and adults with autism. E-1199-22
Investigator Helen Genova ,PhD
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Blood Pressure Modulation with Transcutaneous Spinal Stimulation in Chronic Spinal Cord Injury
Study examines the use of spinal stimulation applied through the skin (referred to as transcutaneous spinal stimulation) in treating orthostatic hypotension (a drop in blood pressure when moving from lying flat on your back to an upright position) in individuals with a spinal cord injury. R-1197-22
Investigator Gail Forrest ,PhD
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Applying Exercise to Improve Memory in TBI
This study compares the effects of two, 12-week exercise programs (aerobic cycling or stretching-and-toning) combined with memory retraining on cognitive (thinking) performance in people with traumatic brain injury. R-1195-22
Investigator Nancy Chiaravalloti ,PhD
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Shockwave Therapy for Individuals with Knee Arthritis
Study examines the effectiveness of a treatment called extracorporeal shockwave therapy on decreasing pain for people with knee osteoarthritis. The shockwave device emits high-frequency sound waves, which interact with different tissues in your body and can provide healing effects. It does not produce electrical shocks. R-1191-22
Investigator Nathan Hogaboom ,
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Use of the KF Modified Story Memory Technique to Improve New Learning and Memory in Individuals with Mild Cognitive Impairment
No description found, try our website link in blue
Investigator Nancy Chiaravalloti ,PhD
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Improving Walking Using a Custom Powered Orthotic after a Lower Leg Injury
This study assesses the comfort, fit, and ease of using a motor powered ankle foot orthosis brace in adults who have had a lower limb injury. D-1182-22
Investigator Karen Nolan ,PhD
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Epidural Spinal Cord Stimulation: Addressing Spasticity and Motor Function
This study aims to expand the knowledge and capacity for neuromodulation to improve the debilitating effects of severe spasticity (spasms, tonic muscle activity and/or clonus) in persons with spinal cord injury. R-1176-22
Investigator Gail Forrest ,PhD
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Comparison of Two Different Group Wellness Programs for People with TBI and their Support Persons
This fully remote or hybrid study compares the effect of two different types of group wellness treatments for individuals with moderate or severe traumatic brain injury and their support persons. R-1157-21
Investigator Denise Krch ,PhD
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Nerve Stimulation for Upper Extremity Recovery in Chronic Cervical Spinal Cord Injury
Study seeks to understand how the combination of upper extremity activity-based recovery training and targeted spinal cord transcutaneous (through the skin) stimulation can improve participants’ ability to use their hand, arms, and trunk. R-1153-21
Investigator Gail Forrest ,PhD
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Rehab of Stroke Reading Deficits Using fMRI Neurofeedback
The purpose of this study is to investigate how reading can be improved after a left-brain stroke. The findings of this study may help to develop new methods for diagnosis and treatment of reading problems after stroke. R-1147-21
Investigator Olga Boukrina ,PhD
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Feedback and Learning in Individuals with Clinical Depression and TBI
The purpose of this research study is to examine the influence of 'feedback timing' (feedback about your performance is either presented immediately or after a delay) on learning and brain function in individuals with moderate to severe TBI with or without depression. Participants complete questionnaires and learning tasks on a computer and while in an MRI scanner. R-1142-21
Investigator Ekaterina Dobryakova ,PhD
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Treatment of Bone Loss in Persons with Chronic Spinal Cord Injury
The purpose of this study is to determine the usefulness of taking Romosozumab for 1 year compared to a placebo (salt solution) followed by 1 year of Denosumab in those who had a spinal cord injury longer than 3 years. Romosozumab and Denosumab are both FDA approved drugs to treat osteoporosis (thinning and weakening of the bone) in those at risk for fracture. D-1101-20
Investigator Steven Kirshblum ,MD
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Targeted Epidural Stimulation for Recovery of Nervous System Function, Movement, and Standing after Severe SCI
This study evaluates the effects of epidural stimulation of the spinal cord on cardiovascular (blood pressure regulation) function, voluntary movement of the legs and trunk, and standing/weight bearing in individuals with spinal cord injury. D-1085-19
Investigator Gail Forrest ,PhD
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Effects of Using a Robotic Exoskeleton Early Post-Stroke
This study assesses whether using a wearable device, called the robotic exoskeleton, can be helpful in improving recovery of walking in adults who have recently had a stroke. R-1073-19
Investigator Karen Nolan ,PhD
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Using Brain Electrical Stimulation to Improve Fatigue and Weakness After Breast Cancer
This study examines how brain stimulation can help improve performance in tasks that normally cause fatigue or weakness in women who have had breast cancer. This study is also enrolling healthy female volunteers who have not had breast cancer for the control group. R-1012-18
Investigator Guang Yue ,PhD
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Robotic Exoskeleton Therapy on Mobility and Cognition in MS
This study examines the usefulness of a wearable robotic exoskeleton device to improve learning, memory, and walking in people with MS. D-983-17
Investigator Ghaith Androwis ,PhD
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Cortical Control of Walking: Brain Plasticity Following Exoskeleton Training in Incomplete Spinal Cord Injury (iSCI)
In this pilot study, we want to study the neural mechanism of walking in able-bodied subjects and iSCI subjects who have some control of muscles below the level of injury (American Spinal Injury Association Impairment Scale (AIS) D). R-940-16
Investigator Gail Forrest ,PhD